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Registration of Natural Medicines

Renewal of Registration of Natural Medicines


How to Apply

Time of application

The registration holder shall submit the renewal application at least 90 days before the expiry of the validity period of the registration of the natural medicine.

Application eligibility

The registration holder of the natural medicine may submit the application.


Documents Required

  1. A duly completed Application Form for Renewal of Registration of Natural Medicines;
  2. Declaration for renewal of registration of the natural medicine;
  3. Test report issued by a pharmaceutical factory or a third-party testing institution for the most recent manufacturing batch of the natural medicine;
  4. For natural medicines manufactured outside the Macao SAR, the original or certified copy of the certificate of registration or sale of the natural medicine issued by the competent authority of the country or region of origin, or of the country or region of provenance, except for natural medicines manufactured in Hengqin in accordance with Chief Executive Dispatch No. 191/2021;
  5. Adverse reaction monitoring report of the natural medicine;
  6. For Improved New Medicines and Innovative Medicines, a report proving that the relevant natural medicine has passed efficacy and stability tests during the validity period of registration shall also be submitted at the time of the first registration renewal.

Location of Application and Service Hours

Location of application: Pharmaceutical Administration Bureau – Department of Registration – Division of Traditional Chinese Medicines

Address: Avenida do Comendador Ho Yin, Edifício de Escritórios do Governo (Qingmao), 19.º andar, Macau

Service hours:
Mondays to Thursdays: 09:00-13:00; 14:30-17:45
Fridays: 09:00-13:00; 14:30-17:30
Closed on Saturdays, Sundays and public holidays


Fees

MOP220.00, including stamp duty.

Note:
In accordance with Article 78(2) of Administrative Regulation No. 46/2021, “paid fees will not be refunded if the application is not accepted, is rejected, or the dossier is filed.”


Application Processing Time

The registration holder shall submit the renewal application at least 90 days before the expiry of the validity period of the registration of the natural medicine.


Relevant Regulations or Requirements

Law No. 11/2021 – Law on Pharmaceutical Activities in Traditional Chinese Medicine and Registration of Proprietary Chinese Medicines

Administrative Regulation No. 46/2021 – Implementing Regulations for the Law on Pharmaceutical Activities in Traditional Chinese Medicine and Registration of Proprietary Chinese Medicines

Technical Instruction of the Pharmaceutical Administration Bureau No. 30/ISAF/2022 – Preparation and Technical Requirements of Information for the Renewal of Registration of Proprietary Chinese Medicines

Chief Executive Dispatch No. 190/2021 – Table of Fees for Pharmaceutical Activities in Traditional Chinese Medicine and Registration of Proprietary Chinese Medicines

Chief Executive Dispatch No. 191/2021 – Stipulates that for proprietary Chinese medicines manufactured in Hengqin, the application for registration or renewal is not required to be accompanied by a certificate of registration or sale issued by the competent authorities of the country or region of origin or provenance


Application Status Enquiry and Result Collection

Method of result collection: In person


Content provider: Pharmaceutical Administration Bureau (ISAF)

Last modified: 2026-07-10 10:52

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All information on this site is based on the official language of the Macao Special Administrative Region. The English version is the translation from the Chinese originals and is provided for reference only. If you find that some of the contents do not have an English version, please refer to the Traditional Chinese or Portuguese versions.